Greg Yothers | School of Public Health

My primary research interest is the design, implementation and analysis of phase II and III clinical trials for cancer research. My work with the NRG Oncology clinical trials group has included trials evaluating therapies for the treatment of colon, rectal, and breast cancer. The focus of my methodological research has been the development of statistical methodologies for identifying a subset of a clinical trial population where a treatment is effective.

I am one of the Primary Investigators for the NRG Oncology Statistics
and Data Management Center (SDMC) - a clinical trials research group comprising
200+ employees. I am the Senior Deputy Director and Deputy Group Statistician for NRG
Oncology SDMC.

Education

2003 | University of Pittsburgh, Pittsburgh, PA | Doctor of Philosophy in Statistics

1998 | University of Pittsburgh, Pittsburgh, PA | Master of Arts in Statistics
1981 | Pennsylvania State University, State College, PA | Bachelor of Science in Mathematics

Selected Publications

Kennecke, H. F., Auer, R., Cho, M., Dasari, N. A., Davies-Venn, C., Eng, C., Dorth, J., Garcia-Aguilar, J., George, M., Goodman, K. A., Kreppel, L., Meyer, J. E., Monzon, J., Saltz, L., Schrag, D., Smith, J. J., Zell, J. A., Das, P., National Cancer Institute Rectal-Anal Task Force. NCI Rectal-Anal Task Force consensus recommendations for design of clinical trials in rectal cancer. Journal of the National Cancer Institute, Dec 2023, 115(12), 1457–1464. https://doi.org/10.1093/jnci/djad143

Taieb, J., Sinicrope, F. A., Pederson, L., Lonardi, S., Alberts, S. R., George, T. J., Yothers, G., Van Cutsem, E., Saltz, L., Ogino, S., Kerr, R., Yoshino, T., Goldberg, R. M., André, T., Laurent-Puig, P., Shi, Q. Different prognostic values of KRAS exon 2 submutations and BRAF V600E mutation in microsatellite stable (MSS) and unstable (MSI) stage III colon cancer: an ACCENT/IDEA pooled analysis of seven trials. Annals of oncology : official journal of the European Society for Medical Oncology, Nov 2023, 34(11), 1025–1034. https://doi.org/10.1016/j.annonc.2023.08.006

Calsavara, V. F., Henry, N. L., Hays, R. D., Kim, S., Luu, M., Diniz, M. A., Gresham, G., Cecchini, R. S., Yothers, G., Ganz, P. A., Rogatko, A., Tighiouart, M. Dynamic Risk Prediction of Treatment Discontinuation Using Patient-Reported Outcomes Data in the Phase III NSABP B-35 Trial. Cancer prevention research (Philadelphia, Pa.), Nov 2023, 16(11), 631–639. https://doi.org/10.1158/1940-6207.CAPR-23-0216

Geyer, C. E., Jr, Blum, J. L., Yothers, G., Asmar, L., Flynn, P. J., Robert, N. J., Hopkins, J. O., O'Shaughnessy, J. A., Rastogi, P., Puhalla, S. L., Hilton, C. J., Dang, C. T., Gómez, H. L., Vukelja, S. J., Lyss, A. P., Paul, D., Brufsky, A. M., Colangelo, L. H., Swain, S. M., Mamounas, E. P., Wolmark, N. Long-Term Follow-Up of the Anthracyclines in Early Breast Cancer Trials (USOR 06-090, NSABP B-46-I/USOR 07132, and NSABP B-49 [NRG Oncology]). Journal of clinical oncology, Apr 2024 42(12), 1344–1349. https://doi.org/10.1200/JCO.23.01428

Chen, L., Wang, Y., Cai, C., Ding, Y., Kim, R. S., Lipchik, C., Gavin, P. G., Yothers, G., Allegra, C. J., Petrelli, N. J., Suga, J. M., Hopkins, J. O., Saito, N. G., Evans, T., Jujjavarapu, S., Wolmark, N., Lucas, P. C., Paik, S., Sun, M., Pogue-Geile, K. L., Lu, X. Machine Learning Predicts Oxaliplatin Benefit in Early Colon Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, May 2024, 42(13), 1520–1530. https://doi.org/10.1200/JCO.23.01080

Gallois, C., Shi, Q., Pederson, L. D., André, T., Iveson, T. J., Sobrero, A. F., Alberts, S., de Gramont, A., Meyerhardt, J. A., George, T., Schmoll, H. E., Souglakos, I., Harkin, A., Labianca, R., Sinicrope, F. A., Oki, E., Shields, A. F., Boukovinas, I., Kerr, R., Lonardi, S., Yothers, G., Yoshino, T., Goldberg, R.M., Taieb, J., Papamichael, D. Oxaliplatin-Based Adjuvant Chemotherapy in Older Patients With Stage III Colon Cancer: An ACCENT/IDEA Pooled Analysis of 12 Trials. Journal of clinical oncology, JCO2301326. Advance online publication Mar 2024. https://doi.org/10.1200/JCO.23.01326

Taieb, J., Basile, D., Seligmann, J., Argiles, G., André, T., Gallois, C., Goldberg, R. M., Yothers, G., Sobrero, A., Meyerhardt, J. A., Souglakos, J., Labianca, R., Iveson, T., Church, D. N., Arnold, D., Tie, J., Gill, S., Laurent-Puig, P., Yoshino, T., Lonardi, S., Shi, Q. Standardizing data collection in adjuvant colon cancer trials: A consensus project from the IDEA and ACCENT international consortia and national experts. European journal of cancer, May 2024, 206:114118. Advance online publication. https://doi.org/10.1016/j.ejca.2024.114118

Department/Affiliation

Biostatistics

Primary Faculty